Define anal cancer
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Related to rectal cancer: hemorrhoids , colon cancer , Stomach cancer. Cancer of the rectum is the disease characterized by the development of malignant cells in the lining or epithelium of the rectum. Malignant cells have changed such that they lose normal control mechanisms governing growth. These cells may invade surrounding local tissue or they may spread throughout the body and invade other organ systems. The rectum is the continuation of the colon part of the large bowel after it leaves the abdomen and descends into the pelvis. It is divided into equal thirds: the upper, mid, and lower rectum.
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Proctitis - Symptoms and causes - Mayo Clinic
The anus is where stool leaves your body when you go to the bathroom. It is made up of your outer layers of skin and the end of your large intestine. Anal cancer is a disease in which cancer cells form in the tissues of the anus. Anal cancer is rare. It is more common in smokers and people over You are also at higher risk if you have HPV , have anal sex, or have many sexual partners. Symptoms include bleeding, pain, or lumps in the anal area.
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Anal intraepithelial neoplasia (AIN)
An abdomino perineal resection , formally known as abdominoperineal resection of the rectum and abdominoperineal excision of the rectum is a surgery for rectal cancer or anal cancer. The principal indication for AP resection is a rectal carcinoma situated in the distal lower one-third of the rectum. APRs involves removal of the anus , the rectum and part of the sigmoid colon along with the associated regional lymph nodes , through incisions made in the abdomen and perineum. The end of the remaining sigmoid colon is brought out permanently as an opening, called a colostomy , on the surface of the abdomen.
Anal canal cancer is rather an uncommon disease but its incidence is increasing. Squamous cell carcinoma SCC is the most frequent primary anal neoplasm and can encompass a variety of morphologies. HPV infection has a key role in precancerous lesions and cancer development by the production of E6 and E7 oncoproteins.
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